Project title
Investigating the roles of human endogenous retroviruses in motor neuron disease
Collaborators and funding
FightMND
Contact(s)
Beben Benyamin, beben.benyamin@adelaide.edu.au
Project description and aims
Project aims:
- To test for differential expression of HERV-K annotated genomic sequences between MND cases and healthy controls.
- To investigate whether HERV-K annotated methylation probes (epigenomic markers) are differently methylated in MND cases compared to healthy controls.
- To identify predictors of MND and its survival by integrating machine learning and classical statistical approaches.
How is ABLeS supporting this work?
This work is supported through the Production Bioinformatics scheme provided by ABLeS.
Expected outputs enabled by participation in ABLeS
We expect to establish an association between a previously unidentified HERV-K subtype and MND. It is also expected to identify the differentially methylated HERV-K genome in MND. Finally, we expect to identify important predictors of MND using machine learning.
These details have been provided by project members at project initiation. For more information on the project, please consult the contact(s) or project links above.