Project title
Haemosphere - An online database of blood cell gene expression
Collaborators and funding
Collaborators:
- Walter and Eliza Hall Medical Research Institute
- St Vincent’s Institute
Contact(s)
- Carolyn de Graaf, degraaf@wehi.edu.au
- Rowland Mosbergen, mosbergen.r@wehi.edu.au
- Jarny Choi, jchoi@svi.edu.au
Project description and aims
During haematopoiesis, haematopoietic stem cells differentiate into restricted potential progenitors before maturing into the many lineages required for oxygen transport, wound healing and immune response. We have updated Haemopedia, a database of gene-expression profiles from a broad spectrum of haematopoietic cells, to include RNA-seq gene-expression data from both mice and humans. The Haemopedia RNA-seq data set covers a wide range of lineages and progenitors, with 57 mouse blood cell types (flow sorted populations from healthy mice) and 12 human blood cell types. Haemosphere also includes nine other publicly available high-quality data sets relevant to haematopoiesis. We have added the ability to compare gene expression across data sets and species by curating data sets with shared lineage designations or to view expression gene vs gene, with all plots available for download by the user.
Haemosphere can be viewed at www.haemosphere.org Published athttps://academic.oup.com/nar/article/47/D1/D780/5160992
How is ABLeS supporting this work?
ABLeS is supporting this project through providing virtual machines to host the platform and make it available to rsearchers.
Expected outputs enabled by participation in ABLeS
We expect that this support will enable the continued use of this resource by the scientific community, with further citations of this project.
These details have been provided by project members at project initiation. For more information on the project, please consult the contact(s) or project links above.