Project title
Applying single cell RNA sequencing to understand the immune landscape of thyroid cancer, with the goal of identifying therapeutic targets and biomarkers.
Collaborators and funding
- Thyroid Cancer Research Group, Faculty of Medicine and Health, University of Sydney
- Kolling Institute of Medical Research
- Sydney Informatics Hub, University of Sydney
Contact(s)
- Dr Martyn Bullock martyn.bullock@sydney.edu.au
- Dr Georgie Samaha georgina.samaha@sydney.edu.au
- Mr Frederick Jaya frederick.jaya@sydney.edu.au
Project description and aims
Understanding the immune composition of thyroid tumours is critical for identifying novel therapeutic targets and predictive biomarkers. Leveraging single-cell RNA sequencing, this study will profile the tumour immune microenvironment at high resolution, enabling the discovery of cell-type-specific expression patterns and pathway dysregulation.
This project will be implemented on NCI’s Gadi HPC, leveraging the open source nf-core/scrnaseq pipeline, and will produce public interactive notebooks for quality control, cell type annotation, differential expression, and biomarker discovery.
How is ABLeS supporting this work?
This work is supported through the production bioinformatics scheme provided by ABLeS. The support includes 2TB storage and 25 KSUs per quarter.
Expected outputs enabled by participation in ABLeS
A public scalable computational workflow and analytical notebooks for single-cell RNA sequencing in cancer cohorts that can be deployed on NCI Gadi.